CBD Studies and Reports – What could it do for you?

– This analysis of previous studies concluded that CBD oil is an effective treatment for several forms of anxiety, including social anxiety disorder (SAD), panic disorder (PD), obsessive-compulsive disorder (OCD), generalized anxiety disorder (GAD) and post-traumatic stress disorder (PTSD).

– In respect of social anxiety disorder specifically, this study focused on Public Speaking concluded that the effects of a single dose of CBD is a promising indication of a rapid onset of therapeutic effect in patients with SAD.

– Also, this study suggests that CBD reduces anxiety in cases of social anxiety and that this is related to its effects on activity in limbic and paralimbic brain areas.

– In this large-scale study about the effect of CBD on children with autism, most of them showed improvements in their anxiety, rage and hyperactivity. The following assessment points showed the patients reported conditions before and 6 months after the treatment: “good quality of life” went from 31.3% of patients to 66.8%; positive mood went from being reported by the parents from 42% to 63.5%; while the ability to dress and shower independently went from 26.4% to 46.9%. Similarly, good sleep and good concentration went from being reported at 3.3% and 0%, to 24.7% and 14%.

– This second study, based on the treatment of children with autism (ASD) with CBD and THC in a ratio of 20:1, showed that behavioral outbreaks were much improved or very much improved in 61% of patients and the anxiety and communication problems were much or very much improved in 39% and 47% respectively. Disruptive behaviors, were improved by 29%.

– This video posted on YouTube portrays the improvement of a child with autism after treatment with CBD oil.

– Several studies on CBD and its effects on cancer, like the one presented here, conclude that “evidence is emerging to suggest that CBD is a potent inhibitor of both cancer growth and spread.”

– On the basis of studies like this one, it is believed that CBD blocks CPR55 signaling, reducing bone resorption and cancer cells proliferation. The CPR55 gene is widely present in the brain, and it is linked to the modulation of bone density and blood pressure, as well as to the proliferation of cancer cells.

– In addition, other recent studies have demonstrated that CBD can reduce the viability of cancer cells in many types of cancer, like the ones listed below:

• Neuroblastoma.
• Glioblastoma.
• Melanoma.
• Leukemia.
• Colorectal cancer.
• Breast cancer.
• Lung cancer.
• Prostate cancer.

– This study shows how the combination of CBD and radiotherapy (RT) achieved greater efficacy in killing pancreatic and lung cancer cells.

– This clinical trial about therapy based on the use of a CBD and THC combination for treating gliomas (brain and spinal cord tumors), specifically glioblastoma multiforme (GBM), shows that it didn’t facilitate the growth of the tumor, and increased patients’ survival rates.

– This other study on breast cancer, claims that “for a highly malignant human breast carcinoma cell line, we have shown here that cannabidiol and a cannabidiol-rich extract counteract cell growth both in vivo and in vitro as well as tumor metastasis in vivo. Cannabidiol exerts its effects on these cells through a combination of mechanisms that include either direct or indirect activation of CB2 and TRPV1 receptors and induction of oxidative stress, all contributing to induce apoptosis [programmed cell death]”.

– This systematic review of randomised clinical trials concluded that 7 out of the 11 analyzed studies demonstrated that CBD relieves the pain through its analgesic effect.

– This study suggested that repeated treatment with low-dose CBD induces analgesia predominantly through TRPV1 receptor activation.

Several studies have succeeded in demonstrating that, in multiple cases of people who suffer from Crohn’s Disease, CBD relieves gut inflammation, consequently raising appetite and decreasing chronic abdominal pain, besides from nausea.

In addition, CBD may relieve the negative side effects of the regularly used anti-inflammatory drugs for treating Crohn’s Disease.

– The following study concludes that CBD possesses an extraordinary range of beneficial effects that may slow the course of the Inflammatory Bowel Disease (collective concept to refer to Crohn’s and ulcerative colitis diseases), ameliorate symptoms and potentially increase the efficacy of the drugs actually available for invalidating it.

– While this other study shows that, after 8 weeks treatment, the Crohn’s-patients group which received CBD oil had a significant reduction in symptoms of the disease, and 65% complied with the strict criteria for the clinical remission (Crohn’s Disease Activity Index (CDAI)<150).

– This study reviews numerous studies about CBD’s effects on depression in animal models, concluding that several of them showed some interaction between CBD and 5-HT1A serotonin neuroreceptor.

– This other study states that CBD could could represent a novel fast antidepressant drug, via increasing both serotonergic and glutamate levels (enhances cortical signalling through a 5-HT1A receptor-dependent mechanism).

– This study on the subject of Prefrontal Cortex of the human brain was shown to suggest that CBD induces a rapid antidepressant effect.

– This study claims that “data available are sufficient to suggest a possible involvement of the endogenous cannabinoid system in the neurobiology of depression”.

– By matching the Endocannabinoid System with diabetes, this study claims that the E.C.S. sets sensitivity of the insulin response in adipocytes, which means that it has an important role in how the body responds to insulin, increasing or decreasing sensitivity to it.

– This other study demonstrated that “CBD reduced circulating resistin concentrations from baseline, while increasing the concentration of circulating GIP”. Increased concentrations of resistin are associated with obesity and insulin resistance. GIP is one of the incretin hormones produced by K cells in the proximal duodenum, which is known to have insulinotropic and pancreatic β-cell–preserving properties”. Also that another cannabis compound called Δ9-tetrahydrocannabivarin (THCV), helped lowering blood glucose levels and increasing insulin production in people with type 2 diabetes.

– Beyond, this article from Fundación Canna stands out, explaining the details of case studies on diabetic pain treatment through CBD and THC in patients with diabetes, as well as the different improvements in may aspects of diabetes via CBD treatment in animal models.

People with anorexia have a less active or weaker Endocannabinoid System than the average, which leads to endocannabinoid deficiencies. With the use of CBD, more endocannabinoids in the system can regulate appetite. CBD’s anxiolytic properties could help alleviate anxiety related to anorexia.

– CBD has the ability to indirectly activate CB1 receptors, which can lead to an appetite stimulation and help to feel the satisfaction when eating, therefore helping people with problems such as anorexia or anorexia nervosa. This orexigenic effect (appetite enhancer) and the rewarding value of food have been demonstrated by this study.

CBD has been shown to reduce the number and severity of seizures, thanks to its anti-seizure properties, as many clinical trials have shown. Prominent among them are studies focused on its benefits for childhood epilepsy.

– In particular, this study demonstrates various facts: 84% of parents whose kids participated in it reported great reductions in their child’s seizure frequency (from 25% to 80%); two of them reported that their child became seizure-free after 4 months of CBD use, and some of them reported weaning their child from other AEDs (anti-epileptic drugs). This s increasing the child’s quality of life by removing negative side effects associated with those other AEDs. Furthermore, many of them related a positive side effects onset, reporting that their children experienced better sleep, increased alertness, and better mood.

– This other study concluded that results suggested that adding CBD to the treatment regimen of kids and teenagers with refractory epilepsy “may result in a significant reduction in seizure frequency according to parental reports”:

– This study, for its part, demonstrated that “4 of the 8 CBD patients who used CBD for their epilepsy, remained almost free of convulsive crises throughout the experiment and 3 other patients demonstrated partial improvement in their clinical condition”.

– This study concludes that “we are beginning to collect sound scientific evidence suggesting that CBD is effective in reducing convulsive seizures in Dravet Syndrome (DS) and drop seizures in Lennox-Gastaut Syndrome (LGS) (two types of epilepsy of infancy which typically don’t respond to anticonvulsant drugs)”, besides its “efficacy in a broader range of TRE (Tumor-Related Epilepsies) including those associated with Tuberous sclerosis complex (TSC), Febrile infection-related epilepsy syndrome (FIRES), focal epilepsy, and other syndromes”.

– In fact, a Harvard Health Publishing article states that “the strongest scientific evidence [of CBD] is for its effectiveness in treating some of the cruelest childhood epilepsy syndromes, such as Dravet syndrome and Lennox-Gastaut syndrome (LGS), which typically don’t respond to antiseizure medications”.

– This study concluded that medical cannabis treatment (THC and CBD) “had a significant favorable effect on patients with fibromyalgia, with few adverse effects”.

– In addition, this other study came to the conclusion that CBD could offset hypersensitivity of the cells surrounding nerves in people with chronic pain, including those with fibromyalgia.

– Finally, this interesting article from Funcación Canna about fibromyalgia, exposes its treatment with CBD, or CBD combined with THC.

During a certain period of the menstrual cycle, the pain that comes with it (dysmenorrhea) is so bothersome to some women that it can inhibit their daily routines. Shortly summarized, a decline in progesterone after the body realizes it is not pregnant causes an increase in chemicals called prostaglandins. These chemicals are inflammatory and bring a varying range of symptoms which many people may identify in having during this time such as: inflammation, heavy bleeding, excruciating pain, heightened pain sensitization in general, diarrhea and uterine contractions.

Some people turn to Nonsteroidal anti-inflammatory drugs (NSAID) such as Ibuprofen to deal with the pains. However, the use of these types of drugs may have some negative effects in some users, such as gastrointestinal discomforts. Good news – CBD has demonstrated similar anti-inflammatory properties, but luckily does not upset the stomach.

– In addition, scientists have recently discovered that CBD (specifically CBDA cannabinoid) inhibits the production of prostaglandins (study), making it a great alternative for relief for those who are dreading that time of every month.

Practicing sports and building your body to become a harder, better, faster and stronger version of yourself comes with a price. Dedication, inflammation, soreness, recovery time and the occasional injury is just part of it.

CBD was removed from a list of prohibited in-competition substances by the WADA in 2018, which is great news for anyone involved in athletics. As a 100% natural alternative to relief and a great addition to your recipe to success, CBD is quickly gaining popularity in sports, being widely appreciated as a natural soothing. FIFA now allows players to use CBD as alternatives to painkillers, and iconic golfers like Tiger Woods and Phil Mickelson are seen using CBD during competition.

– CBD’s anti-inflammatory properties (study here) may be a good reason for its use for post-workout purposes.

– This study talks about the properties of CBD that may improve protein synthesis and reduce inflammation. This can aid in the process of building muscle.

– Adequate recovery is considered a must for any self-demanding athlete. CBD has shown to promote better sleep (sedating effect), as this and this studies point to.

– This trial demonstrated that the CBD oil administration of between 150 – 400 mg to patients without dementia or comorbid psychiatric conditions, increasing the dose until the fourth week, resulted in psychotic symptoms’ reduction as well as in greater average scores in the “well-being and quality of life” measure (via Unified Parkinson’s Disease Rating Scale – UPDRS).

– This other study, conducted with consecutive outpatients, also supports a significant decrease of psychosis in patients under CBD treatment.

– In addition, this case series study concluded CBD can also help to control the symptoms of RBD (REM sleep behaviour disorder) in Parkinson’s patients, a parasomnia characterized by the loss of muscle atonia during REM sleep associated with nightmares and active behaviour during dreaming.

– This trial demonstrated that 10 out of 11 patients in the sample experienced PTSD symptom reduction, after 8 consecutive weeks of treatment with CBD, meeting a 28% of reduction in PCL-5 score, which assesses PTSD symptom severity.

– Following study concludes its results “suggest that CBD has beneficial potential for PTSD treatment and that 5HT1A receptors could be a therapeutic target in this disorder”.

– In addition, this study asserts that “CBD may offer therapeutic benefits for disorders related to inappropriate responses to traumatic memories. The effects of CBD on the different stages of aversive memory processing make this compound a candidate pharmacological adjunct to psychological therapies for PTSD. CBD also shows an action profile with fewer side effects than the pharmacological therapy currently used to treat this type of disorder”.

– Furthermore, this article explores the role of the Endocannabinoid System in treatment development for PTSD, finding that CBD may help in emotional memory processing, focusing on its ability to somehow rewire the brain in cases of traumatic incidents and to allow the victim to process the fact and its consequences.

– This study showed that, in contrast to those placebo treated ones, smokers that used CBD inhalers during trial “significantly reduced the number of cigarettes smoked by ~40%”, also indicating “some maintenance of this effect at follow-up”.

– This other study demonstrated that, in comparison with placebo, a single 800-mg oral dose of cannabidiol reduced attentional bias (AB) from cigarette cues during abstinent sessions, and so the explicit pleasantness of cigarette images.

– This article from Fundación Canna explains the “Use of CBD in treating the tobacco habit“.

According to what various studies suggest, CBD could relieve to some extent the symptoms of inflammation and rheumatoid arthritis-related aches, while also improving the quality of sleep.

– This study explains that “anti-arthritic potency of CBD seems to be the result of a combination of immunosuppression, […] an anti-inflammatory action”.

– This other one explains its anti-inflammation and analgesic effects through its ability to enhance adenosine signaling.

– This study conducted on an animal model claims that “topical CBD application has therapeutic potential for relief of arthritis pain-related behaviours and inflammation without evident side-effects.”

– This one revolves around cannabinoid receptor CB2r in its regulating action on proinflammatory cytokines and MMPs (matrix metalloproteinases) in rheumatoid arthritis, concluding that “CB2r may be a potential therapeutic target of RA”

– This article from Fundación Canna outlines, explaining diverse reliefs to RA symptoms through CBD and THC combined treatment.

– This extensive study, revising several publications about case studies of CBD for schizophrenia, concludes that “results from pre-clinical and clinical studies suggest that CBD is an effective, safe and well-tolerated alternative treatment for schizophrenic patients”.

– This study shows CBD’s effect on anandamide signaling and alleviating psychotic symptoms of schizophrenia.

– This other trial also demonstrates the benefits of CBD around treating psychotic symptoms in patients. The patients seem to not   “[…] depend on dopamine receptor antagonism”, which “[…]may represent a new class of treatment for the disorder”.

CBD, as well as CBD in combination with THC in a 1:1 proportion treatment, could help patients suffering issues related to multiple sclerosis (MS), such as spascity, spasms, bladder issues, tremor or pain.

– Thus, this scientific article about CBD use for improvement of mobility in people with multiple sclerosis, revising 132 original studies, conducted by two americans assistant professor and PhD professor, concludes that “CBD supplementation may be advisable for PwMS to reduce fatigue, pain, spasticity, and ultimately improve mobility”.

– As further instance, this official medical slideshow reports on medical uses of “oral cannabis extract” (pill made of pure CBD) for multiple sclerosis, stating that it has a conclusive/substantial use for improving muscles spasms, as well as strong evidence for reduction in symptoms of spasticity and decrease in patient reported pain (excluding central neuropathic pain).

– Moreover, this other study concludes that “cannabis-based medicine [CBD and THC] is effective in reducing pain and sleep disturbance in patients with multiple sclerosis related central neuropathic pain and is mostly well tolerated”.

Acne breakouts conditions related to skin inflammation are some of the most common problems treated with CBD. Acne is extremely common and while for some people it comes and goes, for others it can be a daily struggle. The good news is that CBD, particularly CBD oil applied topically, may help people deal with this condition, among others. CBD’s antioxidant properties are claimed to be up to 50% more potent than vitamins’ C and E. How could this be important? Antioxidants protect your skin from outer agents that we face everyday, such as air pollution, UV rays and other toxins.

– In fact, CosIng (Cosmetic Ingredients Database from the European Commission for information on cosmetic substances and ingredients) includes antioxidant, antiseborrheic, skin conditioning and skin protection as some of CBD’s functions.

– Findings conducted in this study suggest that “due to the combined lipostatic, antiproliferative, and antiinflammatory effects, CBD has potential as a promising therapeutic agent for the treatment of acne”. CBD’s ability to prevent sebocytes (sebum-secreting cells) from overproducing sebum, suppress cell proliferation and prevent “pro-acne” agents to elevate proinflammatory cytokine levels.

– This study which investigated several cannabinoids including CBD concluded that “our results show that cannabinoids inhibit keratinocyte proliferation, and therefore support a potential role for them in the treatment of psoriasis”.

– This recent study on scars related to psoriasis and atopic dermatitis related scars, showed that “topical treatment with CBD-enriched ointment significantly improved the skin parameters, the symptoms and also the PASI [Psoriasis Area and Severity Index] index score”, concluding that “the topical administration of CBD ointment, without any THC, is a safe and effective non-invasive alternative for improve the quality of life in patients with some skin disorders, specially on inflammatory background”.

Insomnia, causing people to have severe difficulties in falling asleep as well as staying asleep, is usually referred to as one of the main sleep disorders. However, there are over 100 different disorders that can be grouped into three categories:

• Problems staying awake (excessive daytime sleepiness).
• Problems maintaining a regular sleep schedule (sleep rhythm problems).
• Abnormal behaviors during sleep (behaviors that interrupt sleep).

If you have sleep troubles more than three times a week, you should go to the doctor. You shouldn’t let this situation last for over three months, since that’s the point when insomnia is considered as chronic.

– This study, which reviews all the literature published since 2014 on cannabinoids and sleep disorders, concludes that medium and high doses of CBD are sedating, and are associated with an increase in the percentage of total and improved sleep .

– This case study from a patient with PTSD, which shows clinical evidence that CBD is effective as a safe alternative treatment for reducing anxiety and insomnia.

– Other studies conducted in animal models like this one, have demonstrated CBD’s ability to induce sleep, as well as to increase total sleep time (here), and efficiently block anxiety-induced REM sleep suppression (here).